Also known as Erythema multiform major
Most severe and occasionally fatal variant of erythema multiform. The rash is widespread and severe and involves the eyes, mouth, vaginal, urethral, gastrointestinal, respiratory tract and other internal organs. It appears as target like lesions.
Begins with symptoms of non-specific upper respiratory tract infection
Produces fevers
First 1 to 14 days symptoms of fever, sore throat, chills, headache, malaise, and usually vomiting and diarrhea.
Skin loss may lead to dehydration, infection or death
Ocular involvement can include severe onjunctivitis, iritis, conjunctiva and corneal abrasions and corneal perforation.
Occurs in slightly more than 1 to 7 cases per million per year.